Aurora kinase belongs to serine/threonine kinase family which controls cell division.
Therapeutic inhibition of Aurora kinase showed great promise as probable anticancer …

We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

Abstract Purpose of Review Conventional clinico-pathological features in melanoma
patients should be integrated with new molecular diagnostic, predictive, and prognostic …

We report on whole-exome sequencing (WES) of 213 melanomas. Our analysis established
NF1, encoding a negative regulator of RAS, as the third most frequently mutated gene in …

Amino acid deprivation promotes the inhibition of the kinase complex mTORC1 (mammalian
target of rapamycin complex 1) and activation of the kinase GCN2 (general control …

Melanoma is one of the most aggressive tumors of the skin, and its incidence is growing
worldwide. Historically considered a drug resistant disease, since 2011 the therapeutic …

Protein kinases undergo large-scale structural changes that tightly regulate function and
control recognition by small-molecule inhibitors. Methods for quantifying the conformational …

The American Joint Committee on Cancer staging system for cutaneous melanoma is based
on primary tumor thickness and the presence of ulceration, mitoses, lymph node spread, and …

This review presents the accumulating evidence for the roles of protein phosphatase 6 (PP6)
in cell cycle, DNA damage repair, inflammatory signaling, lymphocyte development, virus …

Many eukaryotic protein kinases are activated by phosphorylation on a specific conserved
residue in the regulatory activation loop, a post-translational modification thought to stabilize …