Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …

The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …

Amorphization technology has been the subject of continuous attention in the
pharmaceutical industry, as a means to enhance the solubility of poorly water-soluble drugs …

Introduction Most new drug candidates under development are poorly water-soluble, which
are related to multiple pharmaceutical issues, increasing the bioavailability of these drugs by …

Amino acids are natural compounds that can be safely used in pharmaceutical applications.
Considering the great interest in the amino acids used in the pharmaceutical industry, this …

The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a
relatively recent, widely used approach allowing us to modulate the stability, bio-absorption …

Curcumin (CUR) is the prime curcuminoid in the Indian dietary spice turmeric, Curcuma
longa, a plant of the Zingiberaceae family. CUR has promising and diverse therapeutic …

We have previously developed a fast screening method on the ability of twenty amino acids
(AA) to form co-amorphous formulations with six drugs upon ball milling. In this work, the …

Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active
pharmaceutical ingredient (API) and small molecule excipients. The properties of these …

Co-crystals are one of the most popular ways to modify the physicochemical properties of
active pharmaceutical ingredients (API) without changing pharmacological activity through …