Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules
(MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent …

Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that
bind to microtubules and affect their properties and function. Disruption of microtubules …

Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up
to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces …

Plants have had an essential role in the folklore of ancient cultures. In addition to the use as
food and spices, plants have also been utilized as medicines for over 5000 years. It is …

Dynamic instability, the stochastic switching between growth and shrinkage, is essential for
microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice and …