Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021
Q Wu, W Qian, X Sun, S Jiang - Journal of hematology & oncology, 2022 - Springer
Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials
H Lu, Q Zhou, J He, Z Jiang, C Peng, R Tong… - Signal transduction and …, 2020 - nature.com
Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …
that aberrant PPIs are associated with various diseases, including cancer, infectious …
Therapeutic strategies to overcome taxane resistance in cancer
One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …
emergence of multidrug resistance (MDR). Numerous studies have been published …
Microtubule-targeting agents: strategies to hijack the cytoskeleton
MO Steinmetz, AE Prota - Trends in cell biology, 2018 - cell.com
Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …
the most important medical weapons available to combat cancer. MTAs interfere with …
Control of microtubule organization and dynamics: two ends in the limelight
A Akhmanova, MO Steinmetz - Nature reviews Molecular cell biology, 2015 - nature.com
Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …
division and intracellular transport. They assemble and disassemble from their two ends …
Near-atomic model of microtubule-tau interactions
EH Kellogg, NMA Hejab, S Poepsel, KH Downing… - Science, 2018 - science.org
Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules
(MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent …
(MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent …
[HTML][HTML] Microtubule-targeting agents and their impact on cancer treatment
V Čermák, V Dostál, M Jelínek, L Libusová… - European journal of cell …, 2020 - Elsevier
Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that
bind to microtubules and affect their properties and function. Disruption of microtubules …
bind to microtubules and affect their properties and function. Disruption of microtubules …
Pathomechanisms of paclitaxel-induced peripheral neuropathy
I Klein, HC Lehmann - Toxics, 2021 - mdpi.com
Peripheral neuropathy is one of the most common side effects of chemotherapy, affecting up
to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces …
to 60% of all cancer patients receiving chemotherapy. Moreover, paclitaxel induces …
Plant derived substances with anti-cancer activity: from folklore to practice
M Fridlender, Y Kapulnik, H Koltai - Frontiers in plant science, 2015 - frontiersin.org
Plants have had an essential role in the folklore of ancient cultures. In addition to the use as
food and spices, plants have also been utilized as medicines for over 5000 years. It is …
food and spices, plants have also been utilized as medicines for over 5000 years. It is …
High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis
Dynamic instability, the stochastic switching between growth and shrinkage, is essential for
microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice and …
microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice and …