An integrative multiomics approach to characterize anti‐adipogenic and anti‐lipogenic effects of Akkermansia muciniphila in adipocytes

JS Lee, WS Song, JW Lim, TR Choi, SH Jo… - Biotechnology …, 2022 - Wiley Online Library
The cellular components of Akkermansia muciniphila are considered potential
biotherapeutics for the improvement of obesity, diabetes, and metabolic diseases. However …

Design and in situ biosynthesis of precision therapies against gastrointestinal pathogens

D Durmusoglu, CM Catella, EF Purnell… - Current Opinion in …, 2021 - Elsevier
Gastrointestinal pathogens employ a variety of mechanisms to damage host tissue, acquire
nutrients, and evade treatment. To supplement broad-spectrum antimicrobials, there has …

Development of an in vitro coculture device for the investigation of host–microbe interactions via integrative multiomics approaches

WS Song, SG Shin, SH Jo, JS Lee… - Biotechnology and …, 2021 - Wiley Online Library
The commensal gut bacterium Akkermansia muciniphila is well known as a promising
probiotic candidate that improves host health and prevents diseases. However, the …

Unveiling the inhibition mechanism of Clostridioides difficile by Bifidobacterium longum via multiomics approach

SH Jo, HJ Jeon, WS Song, JS Lee, JE Kwon… - Frontiers in …, 2023 - frontiersin.org
Antibiotic-induced gut microbiota disruption constitutes a major risk factor for Clostridioides
difficile infection (CDI). Further, antibiotic therapy, which is the standard treatment option for …

Evaluating the role of the stringent response mechanism in Clostridioides difficile survival and pathogenesis

A Pokhrel - 2021 - search.proquest.com
The human pathogen Clostridioides difficile causes infections with a high rate of recurrence,
creating an urgent need for new preventive and therapeutic strategies. The stringent …