Tuberculosis is one of the deadliest infectious diseases existing in the world since ancient
times and still possesses serious threat across the globe. Each year the number of cases …

Background Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis;
however, the understanding of resistance mechanisms is poor, which is hampering rapid …

The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) impedes the
End TB Strategy by the World Health Organization aiming for zero deaths, disease, and …

Bedaquiline (BDQ) and clofazimine (CFZ) are core drugs for treatment of multidrug resistant
tuberculosis (MDR-TB), however, our understanding of the resistance mechanisms for these …

In this paper, two series of novel multifunctional 1, 4-di (aryl/heteroaryl) substituted
piperazine derivatives (6a-d & 7a-d) were synthesized, characterized, and evaluated for …

Emerging Mycobacterium tuberculosis (Mtb) resistant strains have continued to limit the
efficacies of existing antitubercular therapies. More specifically, mutations in the RNA …

To survive and establish its niche, Mycobacterium tuberculosis (Mtb) engages in a steady
battle against an array of host defenses and a barrage of antibiotics. Here, we demonstrate …

Аннотация В обзоре приведены данные о частоте выявления микобактерий
туберкулеза (МБТ) с лекарственной устойчивостью (ЛУ), а также об изменении спектра …

Tuberculosis (TB), caused by the Mycobacterium tuberculosis infection, continues to be a
leading cause of morbidity and mortality in developing countries. Resistance to the first-line …

Tuberculosis (TB) continues to be the leading cause of deaths due to its persistent drug
resistance and the consequent ineffectiveness of anti-TB treatment. Recent years witnessed …