[HTML][HTML] Gut microbiome and health: mechanistic insights

WM De Vos, H Tilg, M Van Hul, PD Cani - Gut, 2022 - gut.bmj.com
The gut microbiota is now considered as one of the key elements contributing to the
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …

Gut microbiota in human metabolic health and disease

Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

The intestinal microbiota fuelling metabolic inflammation

H Tilg, N Zmora, TE Adolph, E Elinav - Nature Reviews Immunology, 2020 - nature.com
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

H Han, B Yi, R Zhong, M Wang, S Zhang, J Ma, Y Yin… - Microbiome, 2021 - Springer
Feelings of hunger and satiety are the key determinants for maintaining the life of humans
and animals. Disturbed appetite control may disrupt the metabolic health of the host and …

The incretin hormone GLP‐1 and mechanisms underlying its secretion: 肠促胰岛素激素GLP‐1 及其潜在的分泌机制

L Tian, T Jin - Journal of diabetes, 2016 - Wiley Online Library
摘要胰高血糖素样肽‐1 (Glucagon‐like peptide‐1, GLP‐1) 是一种细胞类型特异性的胰高血糖
素原翻译后产物. 它是由胰高血糖素原基因所编码的, 在激素, 神经元以及营养的刺激下主要由肠 …

Bacterial sensing via neuronal Nod2 regulates appetite and body temperature

I Gabanyi, G Lepousez, R Wheeler, A Vieites-Prado… - Science, 2022 - science.org
Gut bacteria influence brain functions and metabolism. We investigated whether this
influence can be mediated by direct sensing of bacterial cell wall components by brain …

Mechanisms of action and therapeutic application of glucagon-like peptide-1

DJ Drucker - Cell metabolism, 2018 - cell.com
Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-
related glycemic excursions through augmentation of insulin and inhibition of glucagon …

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target

K Wang, Z Zhang, J Hang, J Liu, F Guo, Y Ding, M Li… - Science, 2023 - science.org
A mechanistic understanding of how microbial proteins affect the host could yield deeper
insights into gut microbiota–host cross-talk. We developed an enzyme activity–screening …

Microbial regulation of organismal energy homeostasis

PD Cani, M Van Hul, C Lefort, C Depommier… - Nature …, 2019 - nature.com
The gut microbiome has emerged as a key regulator of host metabolism. Here we review the
various mechanisms through which the gut microbiome influences the energy metabolism of …