1, 2, 3‐Triazole hybrids as anticancer agents: A review

MM Alam - Archiv der Pharmazie, 2022 - Wiley Online Library
Despite the advancements in the development of anticancer agents, more effective and
safer anticancer drugs still need to be developed as the current agents cause unwanted side …

Recent progress in 1H-1, 2, 3-triazoles as potential antifungal agents

N Poonia, A Kumar, V Kumar… - Current Topics in …, 2021 - ingentaconnect.com
The need to overcome ever-increasing cases of antifungal resistance and circumvent side
effects and drug interactions related to currently available drugs has impelled the demand to …

Synthesis of a new sulfadimidine Schiff base and their nano complexes as potential anti-COVID-19 and anti-cancer activity

S Hosny, MS Ragab, RF Abd El-Baki - Scientific Reports, 2023 - nature.com
The primary objective of this study was to describe the cytotoxicity on HEPG-2 cells and to
study the COVID‑19 activities of the novel H2L ligand and its Cr and Cu nano-complexes. As …

Synthesis, structural investigations, DNA/BSA interactions, molecular docking studies, and anticancer activity of a new 1, 4-disubstituted 1, 2, 3-triazole derivative

T Göktürk, E Sakallı Çetin, T Hökelek, H Pekel… - ACS …, 2023 - ACS Publications
We report herein a new 1, 2, 3-triazole derivative, namely, 4-((1-(3, 4-dichlorophenyl)-1 H-1,
2, 3-triazol-4-yl) methoxy)-2-hydroxybenzaldehyde, which was synthesized by copper (I) …

Synthesis, DFT and In Silico Anti-COVID Evaluation of Novel Tetrazole Analogues

J Devasia, S Chinnam, K Khatana… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A new series of 3-aryl/heteroaryl-2-(1 H-tetrazol-5-yl) acrylamides have been synthesized
through catalyst-free, one-pot cascade reactions, utilizing click chemistry approach and …

Targeting the interplay between MMP-2, CA II and VEGFR-2 via new sulfonamide-tethered isomeric triazole hybrids; Microwave-assisted synthesis, computational …

MR Aouad, MA Almehmadi, FF Albelwi, M Teleb… - Bioorganic …, 2022 - Elsevier
Recently, the interest in targeting metalloenzymes is obviously growing for halting various
tumor progression events and surmounting the resistance due to routine chemotherapy …

Zinc Oxide Nanoparticles as Efficient Heterogeneous Catalyst for Synthesis of Bio‐active Heterocyclic Compounds

G Kumar, V Tomar, P Kumar, M Nemiwal - ChemistrySelect, 2023 - Wiley Online Library
Among the most effective recoverable catalytic systems, metal‐oxide nanoparticles (NPs)
are well known for their extensive uses in a broad range of industries, pharmaceuticals, and …

Efficient synthesis, antimicrobial and molecular modelling studies of 3-sulfenylated oxindole linked 1, 2, 3-triazole hybrids

V Kumar, K Lal, A Kumar, RK Tittal, MB Singh… - Research on Chemical …, 2023 - Springer
A novel series of 3-sulfenylated oxindole linked 1, 2, 3-triazole hybrids from 3-sulfenylated
oxindoles bearing a terminal alkyne was efficiently synthesized. After establishing the …

Synthesis of new bioactive indolyl-1, 2, 4-triazole hybrids as dual inhibitors for EGFR/PARP-1 targeting breast and liver cancer cells

MF Youssef, MS Nafie, EE Salama, ATA Boraei… - ACS …, 2022 - ACS Publications
Cancer is the most severe disease worldwide. Every year, tens of millions of people are
diagnosed with cancer, and over half of those people will ultimately die from the disease …

Synthesis, Characterizations, and Quantum Chemical Investigations on Imidazo[1,2-a]pyrimidine-Schiff Base Derivative: (E)-2-Phenyl-N-(thiophen-2-ylmethylene)imidazo[1,2 …

M Azzouzi, O Azougagh, AA Ouchaoui, SE El Hadad… - ACS …, 2023 - ACS Publications
In this study,(E)-2-phenyl-N-(thiophen-2-ylmethylene) imidazo [1, 2-a] pyrimidin-3-amine (3)
is synthesized, and detailed spectral characterizations using 1H NMR, 13C NMR, mass, and …