It is well established that lipid metabolism is drastically altered during tumor development
and response to therapy. Choline kinase alpha (ChoKα) is a key mediator of these changes …

Upregulated choline metabolism, characterized by an increase in phosphocholine (PCho),
is a hallmark of oncogenesis and tumor progression. Choline kinase (ChoK), the enzyme …

A novel family of compounds derivative of 1, 1′-(((ethane-1, 2-diylbis (oxy)) bis (4, 1-
phenylene)) bis (methylene))-bispyridinium or–bisquinolinium bromide (10a-l) containing a …

The UDP-2, 3-diacylglucosamine pyrophosphatase LpxH in the Raetz pathway of lipid A
biosynthesis is an essential enzyme in the vast majority of Gram-negative pathogens and an …

Aim: Research of the antitumor properties of biscationic compounds has received significant
attention over the last few years. Results: A novel family of 1, 1′-([2, 2′-bipyridine]-5, 5 …

This review intends to summarize the structures of an extensive number of symmetrical-
dimeric drugs, having two monomers, linked via a bridging entity emphasizing the versatility …

A large number of different types of cancer have been shown to be associated with an
abnormal metabolism of phosphatidylcholine (PC), the main component of eukaryotic cell …

Abstract Background Choline kinase alpha (ChoKα) is a critical enzyme in the synthesis of
phosphatidylcholine, a major structural component of eukaryotic cell membranes. ChoKα is …

A new series of bis-(aryl-based chalcone) derivatives 9–15 derived from 4, 4′-(ethane-1, 2-
diylbis (oxy))-bis-benzaldehyde (8) were synthesized, via Claisen–Schmidt condensation …

Seeking for new anticancer drugs with strong antiproliferative activity and simple molecular
structure, we designed a novel series of compounds based on our previous reported …