Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining
DA Ramsden, J Carvajal-Garcia… - Nature reviews Molecular …, 2022 - nature.com
Cellular pathways that repair chromosomal double-strand breaks (DSBs) have pivotal roles
in cell growth, development and cancer. These DSB repair pathways have been the target of …
in cell growth, development and cancer. These DSB repair pathways have been the target of …
Deficient mismatch repair/microsatellite unstable colorectal cancer: Diagnosis, prognosis and treatment
Microsatellite unstable (MSI) colorectal cancers (CRCs) are due to DNA mismatch repair
(MMR) deficiency and occurs in15% of non-metastatic diseases and 5% in the metastatic …
(MMR) deficiency and occurs in15% of non-metastatic diseases and 5% in the metastatic …
Nonsense-mediated RNA decay: an emerging modulator of malignancy
K Tan, DG Stupack, MF Wilkinson - Nature Reviews Cancer, 2022 - nature.com
Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathway that
selectively degrades RNAs harbouring truncating mutations that prematurely terminate …
selectively degrades RNAs harbouring truncating mutations that prematurely terminate …
Neoantigens: promising targets for cancer therapy
Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …
Neoadjuvant immunotherapy in primary and metastatic colorectal cancer
A Kanani, T Veen, K Søreide - British Journal of Surgery, 2021 - academic.oup.com
Background Colorectal cancer (CRC) is the second most common solid organ cancer.
Traditional treatment is with surgery and chemotherapy. Immunotherapy has recently …
Traditional treatment is with surgery and chemotherapy. Immunotherapy has recently …
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2
Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19)
vaccination programs globally, which includes administration of mRNA vaccines. Cytokine …
vaccination programs globally, which includes administration of mRNA vaccines. Cytokine …
The broader sense of nonsense
ED Karousis, O Mühlemann - Trends in biochemical sciences, 2022 - cell.com
The term 'nonsense-mediated mRNA decay'(NMD) was initially coined to describe the
translation-dependent degradation of mRNAs harboring premature termination codons …
translation-dependent degradation of mRNAs harboring premature termination codons …
Beta2-microglobulin (B2M) in cancer immunotherapies: Biological function, resistance and remedy
H Wang, B Liu, J Wei - Cancer letters, 2021 - Elsevier
Cancer immunotherapies have made much headway during the past decades. Techniques
including the immune checkpoint inhibition (ICI) and adoptive cell therapy (ACT) have …
including the immune checkpoint inhibition (ICI) and adoptive cell therapy (ACT) have …
Lynch syndrome and MSI-H cancers: from mechanisms to “off-the-shelf” cancer vaccines
V Roudko, C Cimen Bozkus, B Greenbaum… - Frontiers in …, 2021 - frontiersin.org
Defective DNA mismatch repair (dMMR) is associated with many cancer types including
colon, gastric, endometrial, ovarian, hepatobiliary tract, urinary tract, brain and skin cancers …
colon, gastric, endometrial, ovarian, hepatobiliary tract, urinary tract, brain and skin cancers …
Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report …
Summary Background The Prospective Lynch Syndrome Database (PLSD) collates
information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who …
information on carriers of pathogenic or likely pathogenic MMR variants (path_MMR) who …