Germ cells play a unique role in gamete production, heredity and evolution. Therefore, to
understand the mechanisms that specify germ cells is a central challenge in developmental …

“Germ granules” are cytoplasmic, nonmembrane-bound organelles unique to germline.
Germ granules share components with the P bodies and stress granules of somatic cells, but …

This weighty book was written with the objective of providing a summary of the practice of
Drosophila genetics and biology. The emphasis is on experimental methods, the author's …

Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of
the addition of exons from the gene bcr and truncation of the first abl exon. Analysis of …

The piwi family genes, which are defined by conserved PAZ and Piwi domains, play
important roles in stem cell self-renewal, RNA silencing, and translational regulation in …

Activation of the zygotic genome is a prerequisite for the transition from maternal to zygotic
control of development. The onset of zygotic transcription has been well studied in somatic …

To understand the origins and function of the human germ cell lineage and to identify germ
cell-specific markers we have isolated a human ortholog of the Drosophila gene vasa. The …

Summary oskar is one of seven Drosophila maternal-effect genes that are necessary for
germline and abdomen formation. We have cloned oskar and show that oskar RNA is …

Restricted expression of a mouse Vasa homolog gene (Mvh) expression is first detected in
primordial germ cells (PGCs) after colonization of the genital ridges. Subsequently, Mvh is …

In the course of systematic analysis of protein sequences containing the purine NTP-binding
motif, a new superfamily was delineated which included 25 established or putative halicases …