Systems chronotherapeutics

A Ballesta, PF Innominato, R Dallmann, DA Rand… - Pharmacological …, 2017 - ASPET
Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

The pathophysiology of cancer-related fatigue: current controversies

CM O'Higgins, B Brady, B O'Connor, D Walsh… - Supportive Care in …, 2018 - Springer
Fatigue is one of the most common and debilitating cancer symptoms, and is associated with
impaired quality of life. The exact pathophysiology of cancer-related fatigue (CRF) is poorly …

Anamorelin (ONO‐7643) for the treatment of patients with non–small cell lung cancer and cachexia: Results from a randomized, double‐blind, placebo‐controlled …

N Katakami, J Uchino, T Yokoyama, T Naito, M Kondo… - Cancer, 2018 - Wiley Online Library
BACKGROUND Cachexia, described as weight loss (mainly in lean body mass [LBM]) and
anorexia, is common in patients with advanced cancer. This study examined the efficacy and …

[HTML][HTML] Beyond treatment–psychosocial and behavioural issues in cancer survivorship research and practice

NK Aaronson, V Mattioli, O Minton, J Weis… - European Journal of …, 2014 - Elsevier
The population of cancer survivors has grown steadily over the past several decades.
Surviving cancer, however, is not synonymous with a life free of problems related to the …

Screening, evaluation, and management of cancer‐related fatigue: Ready for implementation to practice?

AM Berger, SA Mitchell, PB Jacobsen… - CA: a cancer journal for …, 2015 - Wiley Online Library
Answer questions and earn CME/CNE Evidence regarding cancer‐related fatigue (fatigue)
has accumulated sufficiently such that recommendations for screening, evaluation, and/or …

[HTML][HTML] Supervised exercise reduces cancer-related fatigue: a systematic review

JF Meneses-Echavez, E Gonzalez-Jimenez… - Journal of …, 2015 - Elsevier
Question: Does supervised physical activity reduce cancer-related fatigue? Design:
Systematic review with meta-analysis of randomised trials. Participants: People diagnosed …

Effects of nurse-led home-based exercise & cognitive behavioral therapy on reducing cancer-related fatigue in patients with ovarian cancer during and after …

Q Zhang, F Li, H Zhang, X Yu, Y Cong - International journal of nursing …, 2018 - Elsevier
Background High levels of fatigue have been documented in ovarian cancer patients.
However, increased levels of fatigue are positively associated with a high risk of sleep …

Neuromuscular fatigue during exercise: Methodological considerations, etiology and potential role in chronic fatigue

R Twomey, SJ Aboodarda, R Kruger… - Neurophysiologie …, 2017 - Elsevier
The term fatigue is used to describe a distressing and persistent symptom of physical and/or
mental tiredness in certain clinical populations, with distinct but ultimately complex …

Effects of supervised multimodal exercise interventions on cancer‐related fatigue: systematic review and meta‐analysis of randomized controlled trials

JF Meneses-Echávez… - BioMed research …, 2015 - Wiley Online Library
Objective. Cancer‐related fatigue (CRF) is the most common and devastating problem in
cancer patients even after successful treatment. This study aimed to determine the effects of …

The effectiveness of psychological interventions for fatigue in cancer survivors: systematic review of randomised controlled trials

TK Corbett, A Groarke, D Devane, E Carr, JC Walsh… - Systematic reviews, 2019 - Springer
Background Fatigue is a common symptom in cancer patients that can persist beyond the
curative treatment phase. This systematic review evaluated the effectiveness of …