Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious
public health problem worldwide and lacks effective therapies. Autophagy is a highly …

Despite the decline in their proliferative potential, senescent cells display a high metabolic
activity. Senescent cells have been shown to acquire a more glycolytic state even in …

AKI is associated with high morbidity and mortality, and it predisposes to the development
and progression of CKD. Novel strategies that minimize AKI and halt the progression of CKD …

Nigella sativa seed and its active compounds have been historically recognized as an
effective herbal panacea that can establish a balanced inflammatory response by …

Chronic kidney disease (CKD) is prevalent in 9.1% of the global population and is a
significant public health problem associated with increased morbidity and mortality. CKD is …

Reactive oxygen species (ROS) are highly reactive signaling molecules that maintain redox
homeostasis in mammalian cells. Dysregulation of redox homeostasis under pathological …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative pathogen
of deadly Coronavirus disease-19 (COVID-19) pandemic, which emerged as a major threat …

Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic
fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) …

Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a
peroxisome proliferator-activated receptor-α (PPAR-α) agonist, is a classic drug for treating …

Autophagy is a dynamic process by which intracellular damaged macromolecules and
organelles are degraded and recycled for the synthesis of new cellular components. Basal …