The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …

Background and purpose The FLASH effect is a potential breakthrough in radiotherapy
because ultra-high dose-rate irradiation can substantially widen the therapeutic window …

Simple Summary FLASH radiotherapy (RT) delivering ultra-high dose rate radiation can
reduce normal tissue toxicity while effectively treating tumors. However, implementing …

While FLASH radiation therapy is inspiring enthusiasm to transform the field, it is neither new
nor well understood with respect to the radiobiological mechanisms. As FLASH clinical trials …

Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …

The FLASH effect designates normal tissue sparing at ultra-high dose rate (UHDR,> 40
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …

Purpose Experimental measurements of two‐dimensional (2D) dose rate distributions in
proton pencil beam scanning (PBS) FLASH radiation therapy (RT) are currently lacking. In …

Among the treatments for malignant tumors, radiotherapy is of great significance both as a
main treatment and as an adjuvant treatment. Radiation therapy damages cancer cells with …

Purpose Most current research toward ultra‐high dose rate (FLASH) radiation is conducted
with advanced proton and electron accelerators, which are of limited accessibility to basic …