Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

[HTML][HTML] Do dietary supplements and nutraceuticals have effects on dental implant osseointegration? A scoping review

L Nastri, A Moretti, S Migliaccio, M Paoletta… - Nutrients, 2020 - mdpi.com
Several factors affect dental implant osseointegration, including surgical issues, bone quality
and quantity, and host-related factors, such as patients' nutritional status. Many …

Oncologic doses of zoledronic acid induce osteonecrosis of the jaw‐like lesions in rice rats (Oryzomys palustris) with periodontitis

JI Aguirre, MP Akhter, DB Kimmel… - Journal of Bone and …, 2012 - academic.oup.com
Though osteonecrosis of the jaw (ONJ) is temporally‐associated with the use of nitrogen‐
containing bisphosphonates (N‐BPs), a cause‐and‐effect relationship has not yet been …

High-fat diet disrupts bone remodeling by inducing local and systemic alterations

CC Montalvany-Antonucci, MC Zicker… - The Journal of …, 2018 - Elsevier
A high-fat (HF) diet leads to detrimental effects on alveolar bone (AB); however, the
mechanisms linking adiposity to bone loss are poorly understood. This study investigated if …

Comparison of isoflurane, ketamine–dexmedetomidine, and ketamine–xylazine for general anesthesia during oral procedures in rice rats (Oryzomys palustris)

JM Jiron, JL Mendieta Calle, EJ Castillo… - Journal of the …, 2019 - ingentaconnect.com
Rice rats (Oryzomys palustris) are an unconventional laboratory species that has been used
to study photoperiodicity, periodontitis, and osteonecrosis of the jaw. Interventional …

Preventing or controlling periodontitis reduces the occurrence of osteonecrosis of the jaw (ONJ) in rice rats (Oryzomys palustris)

EJ Castillo, JG Messer, AM Abraham, JM Jiron… - Bone, 2021 - Elsevier
Introduction Osteonecrosis of the jaw (ONJ) is an adverse event that requires association of
both systemic risk factors, such as powerful anti-resorptives (pARs; eg zoledronic acid …

[HTML][HTML] Agreement, correlation, and kinetics of the alveolar bone-loss measurement methodologies in a ligature-induced periodontitis animal model

PK Vargas-Sanchez, MG Moro, FA Santos… - Journal of Applied Oral …, 2017 - SciELO Brasil
Periodontal research involves the use of animal models to better understand the biological
processes of periodontal diseases and the potential of new or existing therapies. Currently …

Zoledronate treatment duration is linked to bisphosphonate‐related osteonecrosis of the jaw prevalence in rice rats with generalized periodontitis

JG Messer, JM Jiron, JL Mendieta Calle… - Oral …, 2019 - Wiley Online Library
Objectives To determine the extent that zoledronate (ZOL) dose and duration is associated
with bisphosphonate‐related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with …

Description of the periodontal pocket in preclinical models: limitations and considerations

N Donos, JC Park, A Vajgel… - Periodontology …, 2018 - Wiley Online Library
Establishment of periodontal health and regeneration of the lost periodontal tissues are
always the ultimate goal of periodontal treatment. The development of new therapeutic …

[HTML][HTML] Bone micro-architectural analysis of mandible and tibia in ovariectomised rats: A quantitative structural comparison between undecalcified histological …

H Liu, W Li, YS Liu, YS Zhou - Bone & Joint Research, 2016 - boneandjoint.org.uk
Objectives This study aims to evaluate if micro-CT can work as a method for the 3D
assessment and analysis of cancellous bone by comparing micro-CT with undecalcified …