BACKGROUND: Blood for transfusion is stored for up to 42 days. Older blood develops
lesions and accumulates potentially injurious substances. Some studies report increasing …

Red cell transfusion therapy is a common treatment modality in contemporary medical
practice. Although blood collection and administration is safer and more efficient than ever …

Importance More than 100 million units of blood are collected worldwide each year, yet the
indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to …

1NHS Blood and Transplant, 2Imperial College Healthcare NHS Trust, London, 3University
College Hospitals NHS Trust, London, 4Serious Hazards of Transfusion, NHS Blood and …

Background Randomized, controlled trials have suggested that the transfusion of blood after
prolonged storage does not increase the risk of adverse outcomes among patients, although …

The impact of transfusing fresher vs older red blood cells (RBCs) on patient-important
outcomes remains controversial. Two recently published large trials have provided new …

Red blood cells (RBC s) degrade progressively during the weeks of refrigerated storage. No
universally accepted definition of 'fresh'or 'old'RBC s exists. While practices vary from …

OBJECTIVE: To test the hypothesis that red blood cell (RBC) transfusions in preterm infants
are associated with increased intra-hospital mortality. STUDY DESIGN: Variables …

Objective To summarize current understanding of the mechanisms responsible for changes
occurring during red blood cell (RBC) storage, collectively known as the storage lesion, and …

Background During cold storage, some red blood cell (RBC) units age more rapidly than
others. Yet, the Food and Drug Administration has set a uniform storage limit of 42 days …