The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
G Hoxhaj, BD Manning - Nature Reviews Cancer, 2020 - nature.com
The altered metabolic programme of cancer cells facilitates their cell-autonomous
proliferation and survival. In normal cells, signal transduction pathways control core cellular …
proliferation and survival. In normal cells, signal transduction pathways control core cellular …
FOXO transcription factors as mediators of stress adaptation
MJ Rodriguez-Colman, TB Dansen… - … Reviews Molecular Cell …, 2024 - nature.com
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
Wild-type and mutated IDH1/2 enzymes and therapy responses
RJ Molenaar, JP Maciejewski, JW Wilmink… - Oncogene, 2018 - nature.com
Abstract Isocitrate dehydrogenase 1 and 2 (IDH1/2) are key enzymes in cellular metabolism,
epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the …
epigenetic regulation, redox states, and DNA repair. IDH1/2 mutations are causal in the …
Mitochondrial function—gatekeeper of intestinal epithelial cell homeostasis
E Rath, A Moschetta, D Haller - Nature reviews Gastroenterology & …, 2018 - nature.com
The intestinal epithelium is a multicellular interface in close proximity to a dense microbial
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …
Investigating the link between ketogenic diet, NAFLD, mitochondria, and oxidative stress: a narrative review
Together with the global rise in obesity and metabolic syndrome, the prevalence of
individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically …
individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically …
[HTML][HTML] Cancer-associated IDH1 promotes growth and resistance to targeted therapies in the absence of mutation
AE Calvert, A Chalastanis, Y Wu, LA Hurley, FM Kouri… - Cell reports, 2017 - cell.com
Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and
IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and …
IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and …
Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis
MC Ludikhuize, M Meerlo, MP Gallego, D Xanthakis… - Cell metabolism, 2020 - cell.com
Differential WNT and Notch signaling regulates differentiation of Lgr5+ crypt-based
columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial …
columnar cells (CBCs) into intestinal cell lineages. Recently we showed that mitochondrial …
Ketone bodies mimic the life span extending properties of caloric restriction
RL Veech, PC Bradshaw, K Clarke, W Curtis… - IUBMB …, 2017 - Wiley Online Library
The extension of life span by caloric restriction has been studied across species from yeast
and Caenorhabditis elegans to primates. No generally accepted theory has been proposed …
and Caenorhabditis elegans to primates. No generally accepted theory has been proposed …
Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
IC Hvinden, T Cadoux-Hudson, CJ Schofield… - Cell Reports …, 2021 - cell.com
The most frequently mutated metabolic genes in human cancer are those encoding the
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …
enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been …
FOXOs: masters of the equilibrium
T Gui, BMT Burgering - The FEBS Journal, 2022 - Wiley Online Library
Forkhead box O (FOXO) transcription factors (TFs) are a subclass of the larger family of
forkhead TFs. Mammalians express four members FOXO1, FOXO3, FOXO4, and FOXO6 …
forkhead TFs. Mammalians express four members FOXO1, FOXO3, FOXO4, and FOXO6 …