On the functional characterization of lytic polysaccharide monooxygenases (LPMOs)

VGH Eijsink, D Petrovic, Z Forsberg, S Mekasha… - Biotechnology for …, 2019 - Springer
Lytic polysaccharide monooxygenases (LPMOs) are abundant in nature and best known for
their role in the enzymatic conversion of recalcitrant polysaccharides such as chitin and …

Oxygen activation by Cu LPMOs in recalcitrant carbohydrate polysaccharide conversion to monomer sugars

KK Meier, SM Jones, T Kaper, H Hansson… - Chemical …, 2017 - ACS Publications
Natural carbohydrate polymers such as starch, cellulose, and chitin provide renewable
alternatives to fossil fuels as a source for fuels and materials. As such, there is considerable …

The impact of hydrogen peroxide supply on LPMO activity and overall saccharification efficiency of a commercial cellulase cocktail

G Müller, P Chylenski, B Bissaro, VGH Eijsink… - Biotechnology for …, 2018 - Springer
Background The discovery of enzymes named lytic polysaccharide monooxygenases
(LPMOs) has had a major impact on the efficiency of current commercial cellulase cocktails …

A fast and sensitive activity assay for lytic polysaccharide monooxygenase

E Breslmayr, M Hanžek, A Hanrahan, C Leitner… - Biotechnology for …, 2018 - Springer
Background Lytic polysaccharide monooxygenases (LPMO) release a spectrum of cleavage
products from their polymeric substrates cellulose, hemicellulose, or chitin. The correct …

Expanding the catalytic landscape of metalloenzymes with lytic polysaccharide monooxygenases

A Munzone, VGH Eijsink, JG Berrin… - Nature Reviews …, 2024 - nature.com
Lytic polysaccharide monooxygenases (LPMOs) have an essential role in global carbon
cycle, industrial biomass processing and microbial pathogenicity by catalysing the oxidative …

Electrochemical monitoring of heterogeneous peroxygenase reactions unravels LPMO kinetics

L Schwaiger, F Csarman, H Chang, O Golten… - ACS …, 2024 - ACS Publications
Biological conversion of plant biomass depends on peroxygenases and peroxidases acting
on insoluble polysaccharides and lignin. Among these are cellulose-and hemicellulose …

Lytic polysaccharide monooxygenases from Myceliophthora thermophila C1 differ in substrate preference and reducing agent specificity

M Frommhagen, MJ Koetsier, AH Westphal… - Biotechnology for …, 2016 - Springer
Abstract Background Lytic polysaccharide monooxgygenases (LPMOs) are known to boost
the hydrolytic breakdown of lignocellulosic biomass, especially cellulose, due to their …

Fast and specific peroxygenase reactions catalyzed by fungal mono-copper enzymes

L Rieder, AA Stepnov, M Sørlie, VGH Eijsink - Biochemistry, 2021 - ACS Publications
The copper-dependent lytic polysaccharide monooxygenases (LPMOs) are receiving
attention because of their role in the degradation of recalcitrant biomass and their intriguing …

Distinct substrate specificities and electron-donating systems of fungal lytic polysaccharide monooxygenases

M Frommhagen, AH Westphal… - Frontiers in …, 2018 - frontiersin.org
Lytic polysaccharide monooxygenases (LPMOs) are powerful enzymes that oxidatively
cleave glycosidic bonds in polysaccharides. The ability of these copper enzymes to boost …

Structural determinants of bacterial lytic polysaccharide monooxygenase functionality

Z Forsberg, B Bissaro, J Gullesen, B Dalhus… - Journal of Biological …, 2018 - ASBMB
Bacterial lytic polysaccharide monooxygenases (LPMO10s) use redox chemistry to cleave
glycosidic bonds in the two foremost recalcitrant polysaccharides found in nature, namely …