Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer

L Colucci-D'Amato, L Speranza, F Volpicelli - International journal of …, 2020 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

[HTML][HTML] Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain

M Miranda, JF Morici, MB Zanoni… - Frontiers in cellular …, 2019 - frontiersin.org
Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

Neurotrophin signalling: novel insights into mechanisms and pathophysiology

M Mitre, A Mariga, MV Chao - Clinical science, 2017 - portlandpress.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

Molecular mechanisms and potential therapeutical targets in Huntington's disease

C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Neurotrophins and their receptors: a convergence point for many signalling pathways

MV Chao - Nature Reviews Neuroscience, 2003 - nature.com
The neurotrophins are a family of proteins that are essential for the development of the
vertebrate nervous system. Each neurotrophin can signal through two different types of cell …

Protective genes and pathways in Alzheimer's disease: moving towards precision interventions

M Seto, RL Weiner, L Dumitrescu… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …

Variant brain-derived neurotrophic factor (BDNF)(Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells …

ZY Chen, PD Patel, G Sant, CX Meng… - Journal of …, 2004 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) plays a critical role in nervous system and
cardiovascular development and function. Recently, a common single nucleotide …

Factors affecting post-stroke motor recovery: implications on neurotherapy after brain injury

A Alawieh, J Zhao, W Feng - Behavioural brain research, 2018 - Elsevier
Neurological disorders are a major cause of chronic disability globally among which stroke
is a leading cause of chronic disability. The advances in the medical management of stroke …

Neurotrophin signalling in health and disease

MV Chao, R Rajagopal, FS Lee - Clinical science, 2006 - portlandpress.com
Neurotrophins are a unique family of polypeptide growth factors that influence the
proliferation, differentiation, survival and death of neuronal and non-neuronal cells. They are …

Role of brain-derived neurotrophic factor in Huntington's disease

C Zuccato, E Cattaneo - Progress in neurobiology, 2007 - Elsevier
Neurotrophic factors are essential contributors to the survival of peripheral and central
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …