Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
[HTML][HTML] Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain
M Miranda, JF Morici, MB Zanoni… - Frontiers in cellular …, 2019 - frontiersin.org
Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …
related to learning and memory. The expression of BDNF is highly regulated, and can lead …
Neurotrophin signalling: novel insights into mechanisms and pathophysiology
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …
of neuronal survival, growth and differentiation during development. While trophic factors are …
Molecular mechanisms and potential therapeutical targets in Huntington's disease
C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
Neurotrophins and their receptors: a convergence point for many signalling pathways
MV Chao - Nature Reviews Neuroscience, 2003 - nature.com
The neurotrophins are a family of proteins that are essential for the development of the
vertebrate nervous system. Each neurotrophin can signal through two different types of cell …
vertebrate nervous system. Each neurotrophin can signal through two different types of cell …
Protective genes and pathways in Alzheimer's disease: moving towards precision interventions
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …
Variant brain-derived neurotrophic factor (BDNF)(Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells …
ZY Chen, PD Patel, G Sant, CX Meng… - Journal of …, 2004 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) plays a critical role in nervous system and
cardiovascular development and function. Recently, a common single nucleotide …
cardiovascular development and function. Recently, a common single nucleotide …
Factors affecting post-stroke motor recovery: implications on neurotherapy after brain injury
Neurological disorders are a major cause of chronic disability globally among which stroke
is a leading cause of chronic disability. The advances in the medical management of stroke …
is a leading cause of chronic disability. The advances in the medical management of stroke …
Neurotrophin signalling in health and disease
MV Chao, R Rajagopal, FS Lee - Clinical science, 2006 - portlandpress.com
Neurotrophins are a unique family of polypeptide growth factors that influence the
proliferation, differentiation, survival and death of neuronal and non-neuronal cells. They are …
proliferation, differentiation, survival and death of neuronal and non-neuronal cells. They are …
Role of brain-derived neurotrophic factor in Huntington's disease
C Zuccato, E Cattaneo - Progress in neurobiology, 2007 - Elsevier
Neurotrophic factors are essential contributors to the survival of peripheral and central
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …
nervous system (CNS) neurons, and demonstration of their reduced availability in diseased …