The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

Transposable elements (TEs) comprise nearly half of the human genome and play an
essential role in the maintenance of genomic stability, chromosomal architecture, and …

Enhancers, critical determinants of cellular identity, are commonly recognized by correlative
chromatin marks and gain-of-function potential, although only loss-of-function studies can …

Multicellular eukaryotic genomes show enormous differences in size. A substantial part of
this variation is due to the presence of transposable elements (TEs). They contribute …

Abstract p53 is a potent tumor suppressor and commonly mutated in human cancers.
Recently, we demonstrated that p53 genes act to restrict retrotransposons in germline …

Population Genetics and Microevolutionary Theory Explore the fundamentals of the
biological implications of population genetic theory In the newly revised Second Edition of …

Large parts of mammalian genomes are transcriptionally inactive and enriched with various
classes of interspersed and tandem repeats. Here we show that the tumor suppressor …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …

Since their discovery, a growing body of evidence has emerged demonstrating that
transposable elements are important drivers of species diversity. These mobile elements …

DNA methylation primarily occurs on CpG dinucleotides and plays an important role in
transcriptional regulations during tissue development and cell differentiation. Over 25% of …