[HTML][HTML] New approach methodologies in human regulatory toxicology–Not if, but how and when!

S Schmeisser, A Miccoli, M von Bergen… - Environment …, 2023 - Elsevier
The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

[HTML][HTML] Application of AOPs to assist regulatory assessment of chemical risks–Case studies, needs and recommendations

L Bajard, O Adamovsky, K Audouze, K Baken… - Environmental …, 2023 - Elsevier
While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …

A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

P Marx-Stoelting, G Rivière, M Luijten… - Archives of …, 2023 - Springer
Current approaches for the assessment of environmental and human health risks due to
exposure to chemical substances have served their purpose reasonably well. Nevertheless …

Perfluoroalkyl and polyfluoroalkyl substances in groundwater used as a source of drinking water in the eastern United States

PB McMahon, AK Tokranov, LM Bexfield… - … science & technology, 2022 - ACS Publications
In 2019, 254 samples were collected from five aquifer systems to evaluate perfluoroalkyl and
polyfluoroalkyl substance (PFAS) occurrence in groundwater used as a source of drinking …

[HTML][HTML] Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

E Drakvik, R Altenburger, Y Aoki, T Backhaus… - Environment …, 2020 - Elsevier
The number of anthropogenic chemicals, manufactured, by-products, metabolites and
abiotically formed transformation products, counts to hundreds of thousands, at present …

Regulatory assessment and risk management of chemical mixtures: challenges and ways forward

SK Bopp, A Kienzler, AN Richarz… - Critical Reviews in …, 2019 - Taylor & Francis
This paper summarizes current challenges, the potential use of novel scientific
methodologies, and ways forward in the risk assessment and risk management of mixtures …

The next frontier of environmental unknowns: substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs)

A Lai, AM Clark, BI Escher, M Fernandez… - Environmental …, 2022 - ACS Publications
Substances of unknown or variable composition, complex reaction products, or biological
materials (UVCBs) are over 70 000 “complex” chemical mixtures produced and used at …

[HTML][HTML] Health risks of solid waste management practices in rural Ghana: A semi-quantitative approach toward a solid waste safety plan

G Vinti, V Bauza, T Clasen, T Tudor, C Zurbrügg… - Environmental …, 2023 - Elsevier
Inadequate solid waste management (SWM) can lead to environmental contamination and
human health risks. The health risks from poor SWM can vary based on specific practices …

[图书][B] Bioanalytical tools in water quality assessment

P Neale, F Leusch, B Escher - 2021 - library.oapen.org
The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012.
The field has exploded since and the second edition updates and reviews the application of …

Application of a framework for grouping and mixtures toxicity assessment of PFAS: A closer examination of dose-additivity approaches

PE Goodrum, JK Anderson, AL Luz… - Toxicological …, 2021 - academic.oup.com
Environmental occurrence and biomonitoring data for per-and polyfluoroalkyl substances
(PFAS) demonstrate that humans are exposed to mixtures of PFAS. This article presents a …