Novel immune checkpoint blockade with ipilimumab, an antibody blocking the cytotoxic T-
lymphocyte antigen 4 (CTLA4), is revolutionizing cancer therapy. However, ipilimumab …

Lynch syndrome (LS) is an autosomal dominant inherited disease caused by germline
pathogenic variants (PVs) in mismatch repair (MMR) genes. LS‐associated endometrial …

Background: Previous research has noted higher cancer mortality rates and lower survival
among males than females. However, systematic comparisons of these two metrics by sex …

Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …

The two oestrogen receptor subtypes α and β are hormone-regulated modulators of
intracellular signalling and gene expression. Regulation of oestrogen receptor activity is …

Colorectal cancer (CRC) is a leading cause of death in the United States. Despite its slow
development and the capacity for early diagnosis, current preventive approaches are not …

Objective. To investigate the association between polymyositis (PM)/dermatomyositis (DM)
and risks of malignancy. Methods. We searched Pubmed for articles dated before August 16 …

Estrogen receptor β (ERβ) is the predominant ER in the colorectal epithelium. Compared
with normal colon tissue, ERβ expression is reduced in colorectal cancer. Our hypothesis is …

Estrogens have been implicated in the pathogenesis of various cancers, with increasing
concern regarding the overall rising incidence of disease and exposure to environmental …

Colon cancer is the third most common cancer worldwide, with high mortality. Adverse side
effects and chemoresistance of the first-line chemotherapy 5-fluorouracil (5-FU) have …