IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in
numerous cancer types, including more than 40% of breast cancers. In contrast to tight …

Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …

Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …

We have investigated the importance of interleukin-6 (IL-6) in promoting tumor growth and
metastasis. In human primary breast cancers, increased levels of IL-6 were found at the …

Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

Although inactivation of the PTEN gene has been implicated in the development of
resistance to the HER2 targeting antibody trastuzumab, the mechanisms mediating this …

Triple-negative breast cancers (TNBC) are aggressive with no effective targeted therapies. A
combined database analysis identified 32 inflammation-related genes differentially …

Simple Summary Trastuzumab is a humanized antibody that has significantly improved the
management and treatment outcomes of patients with cancers that overexpress HER2 …

Background Inflammatory breast cancer (IBC), a particularly aggressive form of breast
cancer, is characterized by cancer stem cell (CSC) phenotype. Due to a lack of targeted …