IgA nephropathy: an interesting autoimmune kidney disease
A Rajasekaran, BA Julian, DV Rizk - The American journal of the medical …, 2021 - Elsevier
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …
IgA nephropathy
JC Rodrigues, M Haas, HN Reich - Clinical Journal of the …, 2017 - journals.lww.com
IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international
collaborative efforts have led to important discoveries that have improved our understanding …
collaborative efforts have led to important discoveries that have improved our understanding …
Effect of oral methylprednisolone on decline in kidney function or kidney failure in patients with IgA nephropathy: the TESTING randomized clinical trial
Importance The effect of glucocorticoids on major kidney outcomes and adverse events in
IgA nephropathy has been uncertain. Objective To evaluate the efficacy and adverse effects …
IgA nephropathy has been uncertain. Objective To evaluate the efficacy and adverse effects …
The mucosal immune system and IgA nephropathy
L Gesualdo, V Di Leo, R Coppo - Seminars in immunopathology, 2021 - Springer
The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly
established but emerging evidence confirms a pivotal role for mucosal immunity. This review …
established but emerging evidence confirms a pivotal role for mucosal immunity. This review …
IgA nephropathy
Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …
[HTML][HTML] Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies …
J Floege, SJ Barbour, DC Cattran, JJ Hogan… - Kidney international, 2019 - Elsevier
The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a
Controversies Conference on glomerular diseases in November 2017. The conference …
Controversies Conference on glomerular diseases in November 2017. The conference …
[HTML][HTML] Safety, tolerability and efficacy of narsoplimab, a novel MASP-2 inhibitor for the treatment of IgA nephropathy
RA Lafayette, BH Rovin, HN Reich, JA Tumlin… - Kidney international …, 2020 - Elsevier
Introduction Narsoplimab is a human monoclonal antibody against mannan-associated
lectin-binding serine protease− 2 (MASP-2). Now in a phase 3 study, narsoplimab was …
lectin-binding serine protease− 2 (MASP-2). Now in a phase 3 study, narsoplimab was …
[HTML][HTML] Results of a randomized double-blind placebo-controlled Phase 2 study propose iptacopan as an alternative complement pathway inhibitor for IgA …
H Zhang, DV Rizk, V Perkovic, B Maes, N Kashihara… - Kidney international, 2024 - Elsevier
Targeting the alternative complement pathway is an attractive therapeutic strategy given its
role in the pathogenesis of immunoglobulin A nephropathy (IgAN). Iptacopan (LNP023) is …
role in the pathogenesis of immunoglobulin A nephropathy (IgAN). Iptacopan (LNP023) is …
The emerging role of complement proteins as a target for therapy of IgA nephropathy
DV Rizk, N Maillard, BA Julian, B Knoppova… - Frontiers in …, 2019 - frontiersin.org
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …
The role of complement in IgA nephropathy
A Tortajada, E Gutierrez, MC Pickering, MP Terente… - Molecular …, 2019 - Elsevier
IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN
encompasses a wide range of histology and clinical features. IgAN pathogenesis is …
encompasses a wide range of histology and clinical features. IgAN pathogenesis is …