The genesis and evolution of acute myeloid leukemia stem cells in the microenvironment: From biology to therapeutic targeting
Y Chen, J Li, L Xu, MA Găman, Z Zou - Cell Death Discovery, 2022 - nature.com
Acute myeloid leukemia (AML) is a hematological malignancy characterized by cytogenetic
and genomic alterations. Up to now, combination chemotherapy remains the standard …
and genomic alterations. Up to now, combination chemotherapy remains the standard …
Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic
JP Bewersdorf, O Abdel-Wahab - Genes & Development, 2022 - genesdev.cshlp.org
Despite FDA approval of nine new drugs for patients with acute myeloid leukemia (AML) in
the United States over the last 4 years, AML remains a major area of unmet medical need …
the United States over the last 4 years, AML remains a major area of unmet medical need …
Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
SN Stacey, F Zink, GH Halldorsson, L Stefansdottir… - Nature Genetics, 2023 - nature.com
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive
complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB) …
complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB) …
ASXL1 mutations predict inferior molecular response to nilotinib treatment in chronic myeloid leukemia
L Schönfeld, J Rinke, A Hinze, SN Nagel, V Schäfer… - Leukemia, 2022 - nature.com
Gene mutations independent of BCR:: ABL1 have been identified in newly diagnosed
patients with chronic myeloid leukemia (CML) in chronic phase, whereby mutations in …
patients with chronic myeloid leukemia (CML) in chronic phase, whereby mutations in …
Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer
Cell identity is tightly controlled by specific transcriptional programs which require post-
translational modifications of histones. These histone modifications allow the establishment …
translational modifications of histones. These histone modifications allow the establishment …
Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS …
JP Bewersdorf, Z Xie, R Bejar, U Borate, J Boultwood… - Blood Reviews, 2023 - Elsevier
Biological events that contribute to the pathogenesis of myelodysplastic
syndromes/neoplasms (MDS) are becoming increasingly characterized and are being …
syndromes/neoplasms (MDS) are becoming increasingly characterized and are being …
Mechanisms of myeloid leukemogenesis: Current perspectives and therapeutic objectives
IM Bouligny, KR Maher, S Grant - Blood reviews, 2023 - Elsevier
Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in
clonal proliferation of abnormally differentiated hematopoietic cells. In this review …
clonal proliferation of abnormally differentiated hematopoietic cells. In this review …
Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase
Repression of gene expression by protein complexes of the Polycomb group is a
fundamental mechanism that governs embryonic development and cell-type specification …
fundamental mechanism that governs embryonic development and cell-type specification …
ASXL1/2 mutations and myeloid malignancies
EA Medina, CR Delma, FC Yang - Journal of Hematology & Oncology, 2022 - Springer
Myeloid malignancies develop through the accumulation of genetic and epigenetic
alterations that dysregulate hematopoietic stem cell (HSC) self-renewal, stimulate HSC …
alterations that dysregulate hematopoietic stem cell (HSC) self-renewal, stimulate HSC …