Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Several collagen subtypes have been identified in hyaline articular cartilage. The main and
most abundant collagens are type II, IX and XI collagens. The minor and less abundant …

Aging is a natural process characterized by the declining ability of the different organs and
tissues to respond to stress, increasing homeostatic imbalance and risk of disease …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Chondrocytes of the growth plate undergo apoptosis during the process of endochondral
ossification, as well as during the progression of osteoarthritis. Although the regulation of …

Aging is the most prominent risk factor triggering several degenerative diseases, such as
osteoarthritis (OA). Due to its poor self-healing capacity, once injured cartilage needs to be …

Objective To determine whether altered IL8 methylation status is associated with increased
expression of IL8 in human osteoarthritic (OA) chondrocytes. Methods IL8 expression levels …

Osteoarthritis (OA) is the most common type of arthritis and no longer is considered as an
absolute consequence of joint mechanical use (wear and tear); rather recent data …