JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands

A Chowdhury, CM Modahl, ST Tan… - PLoS …, 2020 - journals.plos.org
Arbovirus infection of Aedes aegypti salivary glands (SGs) determines transmission.
However, there is a dearth of knowledge on SG immunity. Here, we characterized SG …

The Aedes aegypti siRNA pathway mediates broad-spectrum defense against human pathogenic viruses and modulates antibacterial and antifungal defenses

Y Dong, S Dong, NB Dizaji, N Rutkowski… - PLoS …, 2022 - journals.plos.org
The mosquito's innate immune system defends against a variety of pathogens, and the
conserved siRNA pathway plays a central role in the control of viral infections. Here, we …

Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti

L Danet, G Beauclair, M Berthet… - PLoS neglected …, 2019 - journals.plos.org
Background To be transmitted to vertebrate hosts via the saliva of their vectors, arthropod-
borne viruses have to cross several barriers in the mosquito body, including the midgut …

Loquacious modulates flaviviral RNA replication in mosquito cells

S Shivaprasad, KF Weng, YS Ooi, J Belk… - PLoS …, 2022 - journals.plos.org
Arthropod-borne viruses infect both mosquito and mammalian hosts. While much is known
about virus-host interactions that modulate viral gene expression in their mammalian host …

Tudor-SN promotes early replication of dengue virus in the Aedes aegypti midgut

S Hélène Merkling, V Raquin, S Dabo… - bioRxiv, 2019 - biorxiv.org
Diseases caused by mosquito-borne viruses have been on the rise for the last decades,
despite the implementation of vector control methods primarily based on insecticides. An …