The specificity of cellular responses to receptor stimulation is encoded by the spatial and
temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to …

Realizing the promise of molecularly targeted inhibitors for cancer therapy will require a new
level of knowledge about how a drug target is wired into the control circuitry of a complex …

The Wnt and the extracellular signal regulated-kinase (ERK) pathways are both involved in
the pathogenesis of various kinds of cancers. Recently, the existence of crosstalk between …

Organisms have the property to adapt to a changing environment and keep certain
components within a cell regulated at the same level (homeostasis)." Perfect adaptation" …

Cycles involving covalent modification of proteins are key components of the intracellular
signaling machinery. Each cycle is comprised of two interconvertable forms of a particular …

Embryonic development and adult tissue homeostasis are controlled through activation of
intracellular signal transduction pathways by extracellular growth factors. In the past, signal …

The use of strong promoter systems for recombinant protein production generates high
product yields, but also overburdens the host cell metabolism and compromises production …

The analysis of complex biochemical networks is conducted in two popular conceptual
frameworks for modelling. The deterministic approach requires the solution of ordinary …

Signal transduction is the process by which the cell converts one kind of signal or stimulus
into another. This involves a sequence of biochemical reactions, carried out by proteins. The …

Motivated by applications in systems biology, a probabilistic framework based on Markov
processes is proposed to represent intracellular processes. The formal relationships …