Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

Background Alzheimer's disease (AD) prevalence is increasing, but its etiology remains
elusive. Gut microbes can contribute to AD pathology and may help identifying novel …

The gut microbiota is a complex system, consisting of a dynamic population of
microorganisms, involved in the regulation of the host's homeostasis. A vast number of …

The gut microbiota comprises a complex community of microorganism species that resides
in our gastrointestinal ecosystem and whose alterations influence not only various gut …

Accumulation of toxic protein aggregates—amyloid-β (Aβ) plaques and
hyperphosphorylated tau tangles—is the pathological hallmark of Alzheimer disease (AD) …

Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …

It has been hypothesized that alterations in the composition of the gut microbiota might be
associated with the onset of certain human pathologies, such as Alzheimer disease, a …

CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …

The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …