Neural inhibition in the brain is mainly mediated by ionotropic γ-aminobutyric acid type A
(GABAA) receptors. Different subtypes of these receptors, distinguished by their subunit …

Single-molecule approaches give access to the full distribution of molecule behaviors and
overcome the averaging intrinsic to bulk measurement methods. They allow access to …

The mechanisms that govern receptor coalescence into functional clusters—often a critical
step in their stimulation by ligand—are poorly understood. We used single-molecule tracking …

The fragile X mental retardation protein (FMRP) is a selective RNA-binding protein
implicated in regulating translation of its mRNA ligands. The absence of FMRP results in …

A fundamental feature of membranes is the lateral diffusion of lipids and proteins. Control of
lateral diffusion provides a mechanism for regulating the structure and function of synapses …

The superfamily of G protein-coupled receptors (GPCRs) mediates a wide range of
physiological responses and serves as an important category of drug targets. Earlier …

Background: Mitochondrial inheritance is essential for cell division. In budding yeast,
mitochondrial movement from mother to daughter requires (1) actin cables, F-actin bundles …

Fragile X syndrome, the most common form of inherited mental retardation, is caused by
absence of FMRP, an RNA-binding protein implicated in regulation of mRNA translation …

There is mounting evidence that the plasma membrane is highly dynamic and organized in
a complex manner. The cortical cytoskeleton is proving to be a particularly important …

Molecular interactions are often transient and might change within the window of
observation, leading to changes in molecule movement. Therefore, accurate motion analysis …