The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …

Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a
significant proportion of patients with myeloid malignancies. Although there are extensive …

Recent genomic studies have identified novel recurrent somatic mutations in patients with
myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic …

Post-translational modification of histones provides an important regulatory platform for
processes such as gene transcription and DNA damage repair. It has become increasingly …

It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group
of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA …

Purpose Glioblastomas are notorious for resistance to therapy, which has been attributed to
DNA-repair proficiency, a multitude of deregulated molecular pathways, and, more recently …

Human cancers often carry many somatically acquired genomic rearrangements, some of
which may be implicated in cancer development. However, conventional strategies for …

Aggressive leukemias arise in both children and adults as a result of rearrangements to the
mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL encodes a large …