Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …

Oligodendrocytes produce myelin, an insulating sheath required for the saltatory conduction
of electrical impulses along axons. Oligodendrocyte loss results in demyelination, which …

The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in
devising potential cell-based therapeutic strategies for central nervous system (CNS) …

Oligodendrocytes and the myelin they produce are a remarkable vertebrate specialization
that enables rapid and efficient nerve conduction within the central nervous system. The …

The restoration of myelin sheaths on demyelinated axons remains a major obstacle in the
treatment of multiple sclerosis (MS). Currently approved therapies work by modulating the …

Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of
regenerative medicine. Extraordinary efforts have been made to understand developmental …

The adult mouse subependymal zone (SEZ) harbours adult neural stem cells (aNSCs) that
give rise to neuronal and oligodendroglial progeny. However it is not known whether the …

Glial cells that express the NG2 proteoglycan and the α receptor for PDGF (NG2 cells,
polydendrocytes) make up the fifth major cell population that serves as oligodendrocyte …

The straightforward concept that accentuated Wnt signaling via the Wnt‐receptor‐β‐catenin‐
TCF/LEF cascade (also termed canonical Wnt signaling or Wnt/β‐catenin signaling) delays …

The expression of the gut tumor suppressor gene adenomatous polyposis coli (Apc) and its
role in the oligodendroglial lineage are poorly understood. We found that immunoreactive …