Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …

Summary mRNA processing, transport, translation, and ultimately degradation involve a
series of dedicated protein complexes that often assemble into large membraneless …

Stress granules are condensates of non-translating mRNAs and proteins involved in the
stress response and neurodegenerative diseases. Stress granules form in part through …

Dysregulation of protein translation is a key driver for the pathogenesis of many cancers.
Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a …

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA
translation represents an attractive cancer therapy. Here, we show that therapeutically …

Altered eIF4A1 activity promotes translation of highly structured, eIF4A1-dependent
oncogene mRNAs at root of oncogenic translational programmes. It remains unclear how …

Zika virus (ZIKV), a member of the Flaviviridae family, has recently emerged as an important
human pathogen with increasing economic and health impact worldwide. Because of its …

Reversible monoubiquitination of small subunit ribosomal proteins RPS2/uS5 and
RPS3/uS3 has been noted to occur on ribosomes involved in ZNF598-dependent mRNA …

Stress granules (SGs) are assemblies of mRNA and proteins that form from mRNAs stalled
in translation initiation in response to stress. Chronic stress might even induce formation of …