It has been thought that caloric restriction favors longevity and healthy aging where
autophagy plays a vital role. However, autophagy decreases during aging and that can lead …

Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins
and organelles, is now recognized as an anti-aging process. In addition to its basal role in …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Many researchers, especially those new to the field, need to determine which criteria are
essential for demonstrating autophagy, either for the purposes of their own research, or in …

Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by
tethering enveloped virions to the cell surface to restrict viral release and by inducing the …

Nanostructured titanium implants are recognized for inducing osteogenesis, but the cell
signal transductions related to topography are not fully understood. Implant topography is …

Homeostasis is maintained within organisms through the physiological recycling process of
autophagy, a catabolic process that is intricately involved in the mobilization of nutrients …

Autophagy is a degradative pathway for cytoplasmic constituents, and is conserved across
eukaryotes. Autophagy-related (ATG) genes have undergone extensive multiplications and …

Gemcitabine (GEM) resistance in pancreatic adenocarcinoma mediated by the receptor for
advanced glycation end products (RAGE) has been demonstrated. Therefore, investigating …

The high prevalence of neurodegenerative diseases has become a major public health
challenge and is associated with a tremendous burden on individuals, society and federal …