Mechanisms, diagnosis and treatment of bone metastases
Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …
An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma
DS Shulman, SB Whittle, D Surdez, KM Bailey… - NPJ precision …, 2022 - nature.com
The advent of dose intensified interval compressed therapy has improved event-free survival
for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a …
for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a …
TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
Fusion-transcription factors (fusion-TFs) represent a class of driver oncoproteins that are
difficult to therapeutically target. Recently, protein degradation has emerged as a strategy to …
difficult to therapeutically target. Recently, protein degradation has emerged as a strategy to …
The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma
Transcription factors (TFs) are frequently mutated in cancer. Paediatric cancers exhibit few
mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which …
mutations genome-wide but frequently harbour sentinel mutations that affect TFs, which …
ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation
The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer
Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the …
Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the …
VRK1 is a synthetic–lethal target in VRK2-deficient glioblastoma
JA Shields, SR Meier, M Bandi, EE Mulkearns-Hubert… - Cancer Research, 2022 - AACR
Synthetic lethality is a genetic interaction that results in cell death when two genetic
deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for …
deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for …
Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma
Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases,
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …
Full circle: a brief history of cohesin and the regulation of gene expression
JA Horsfield - The FEBS journal, 2023 - Wiley Online Library
The cohesin complex has a range of crucial functions in the cell. Cohesin is essential for
mediating chromatid cohesion during mitosis, for repair of double‐strand DNA breaks, and …
mediating chromatid cohesion during mitosis, for repair of double‐strand DNA breaks, and …
Adverse prognostic impact of the loss of STAG2 protein expression in patients with newly diagnosed localised Ewing sarcoma: A report from the Children's Oncology …
DS Shulman, S Chen, D Hall, A Nag… - British Journal of …, 2022 - nature.com
Background Ewing sarcoma (EWS) is an aggressive sarcoma with no validated molecular
biomarkers. We aimed to determine the frequency of STAG2 protein loss by …
biomarkers. We aimed to determine the frequency of STAG2 protein loss by …
EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma
IA Showpnil, J Selich-Anderson, C Taslim… - Nucleic Acids …, 2022 - academic.oup.com
Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that
expresses EWS/FLI or a highly related FET/ETS chimera. EWS/FLI dysregulates …
expresses EWS/FLI or a highly related FET/ETS chimera. EWS/FLI dysregulates …