Since the work of Golgi and Cajal, light microscopy has remained a key tool for
neuroscientists to observe cellular properties. Ongoing advances have enabled new …

The plasma membrane is the final barrier that enveloped viruses must cross during their
egress from the infected cell. Here, we review recent insights into the cell biology of retroviral …

Cellular messenger RNA levels are achieved by the combinatorial complexity of factors
controlling transcription, yet the small number of molecules involved in these pathways …

The HIV-1 accessory protein Vpu counteracts a host factor that restricts virion release from
infected cells. Here we show that the interferon-induced cellular protein BST-2/HM1 …

Messenger RNA decay measurements are typically performed on a population of cells.
However, this approach cannot reveal sufficient complexity to provide information on …

The expression of many putative antiviral genes is upregulated when cells encounter type I
interferon (IFN), but the actual mechanisms by which many IFN-induced gene products …

The incorporation of viral genomes into particles has never previously been imaged in live
infected cells. Thus, for many viruses it is unknown how the recruitment and packaging of …

Synthesis of mRNA in eukaryotes involves the coordinated action of many enzymatic
processes, including initiation, elongation, splicing, and cleavage. Kinetic competition …

Observations of individual virions in live cells have led to the characterization of their
attachment, entry and intracellular transport. However, the assembly of individual virions has …

Invadopodia are invasive protrusions with proteolytic activity uniquely found in tumor cells.
Cortactin phosphorylation is a key step during invadopodia maturation, regulating Nck1 …