The heart contains a population of resident macrophages that markedly expands following
injury through recruitment of monocytes and through proliferation of macrophages. In …

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with
perplexing heterogeneity in disease manifestation and response to treatment. While the …

NRG1 (Neuregulin-1) is an effective cardiomyocyte proliferator, secreted and released by
endothelial vascular cells, and affects the cardiovascular system. It plays a major role in …

Cardiac fibroblasts are a cell population that controls the homeostasis of the extracellular
matrix and orchestrates a damage response to maintain cardiac architecture and …

Cellular senescence is characteristic of the development and progression of multiple age-
associated diseases. Accumulation of senescent cells in the heart contributes to various age …

Chronic kidney disease is a global health problem affecting 10% to 12% of the population.
Uremic cardiomyopathy is often characterized by left ventricular hypertrophy, fibrosis, and …

The inhibition of mammalian target of rapamycin (mTOR) with rapamycin (RAPA) provides
protection against myocardial ischemia/reperfusion (I/R) injury in diabetes. Since …

Abstract Introduction N6-methyladenosine (m6A) methylation produces a marked effect on
cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an m6A …

Fibrosis can occur in all major organs with relentless progress, ultimately leading to organ
failure and potentially death. Unfortunately, current clinical treatments cannot prevent or …