Vulnerable atherosclerotic plaque: is there a molecular signature?

RM Chiorescu, M Mocan, AI Inceu, AP Buda… - International Journal of …, 2022 - mdpi.com
Atherosclerosis and its clinical manifestations, coronary and cerebral artery diseases, are
the most common cause of death worldwide. The main pathophysiological mechanism for …

Interactions between morphological plaque characteristics and coronary physiology: from pathophysiological basis to clinical implications

S Yang, BK Koo, J Narula - Cardiovascular Imaging, 2022 - jacc.org
High-risk coronary plaque refers to a distinct set of plaque characteristics prone to future
coronary events. Coronary physiology represents a group of indexes reflective of the local …

Automated analysis of fibrous cap in intravascular optical coherence tomography images of coronary arteries

J Lee, GTR Pereira, Y Gharaibeh, C Kolluru… - Scientific Reports, 2022 - nature.com
Thin-cap fibroatheroma (TCFA) and plaque rupture have been recognized as the most
frequent risk factor for thrombosis and acute coronary syndrome. Intravascular optical …

Fully automated construction of three-dimensional finite element simulations from Optical Coherence Tomography

R Straughan, K Kadry, SA Parikh, ER Edelman… - Computers in Biology …, 2023 - Elsevier
Despite recent advances in diagnosis and treatment, atherosclerotic coronary artery
diseases remain a leading cause of death worldwide. Various imaging modalities and …

Effect of variability of mechanical properties on the predictive capabilities of vulnerable coronary plaques

M Stefanati, A Corti, VDA Corino, MR Bennett… - Computer Methods and …, 2024 - Elsevier
Abstract Background and Objective: Coronary plaque rupture is a precipitating event
responsible for two thirds of myocardial infarctions. Currently, the risk of plaque rupture is …

Advantages and prospects of optical coherence tomography in interventional therapy of coronary heart disease

J Wang, S Yuan, J Qi, Q Zhang… - Experimental and …, 2022 - spandidos-publications.com
Coronary heart disease is the leading cause of mortality among all diseases globally.
Percutaneous coronary intervention (PCI) is a key method for the treatment of coronary heart …

Combining IVUS+ OCT data, biomechanical models and machine learning method for accurate coronary plaque morphology quantification and cap thickness and …

R Lv, L Wang, A Maehara, M Matsumura… - Journal of functional …, 2023 - mdpi.com
Assessment and prediction of vulnerable plaque progression and rupture risk are of utmost
importance for diagnosis, management and treatment of cardiovascular diseases and …

Prevalence, morphology, and predictors of intra-stent plaque rupture in patients with acute coronary syndrome: An optical coherence tomography study

H Yu, J Dai, C Fang, S Jiang… - Clinical and Applied …, 2022 - journals.sagepub.com
Previous studies have shown that plaque rupture (PR) is the most important cause of acute
coronary syndrome (ACS). However, the potential impact of intra-stent PR on stent failure …

Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries

TNAM Vuong, M Bartolf‐Kopp, K Andelovic… - Advanced …, 2024 - Wiley Online Library
Atherosclerosis is the primary cause of cardiovascular disease, resulting in mortality,
elevated healthcare costs, diminished productivity, and reduced quality of life for individuals …

Plaque Ruptures Are Related to High Plaque Stress and Strain Conditions: Direct Verification by Using In Vivo OCT Rupture Data and FSI Models

C Zhao, R Lv, A Maehara, L Wang, Z Gao… - … and Vascular Biology, 2024 - Am Heart Assoc
BACKGROUND: While it has been hypothesized that high plaque stress and strain may be
related to plaque rupture, its direct verification using in vivo coronary plaque rupture data …