Salvia divinorum and Mitragyna speciosa (“Kratom”), two unscheduled dietary supplements
whose active agents are opioid receptor agonists, have discrete psychoactive effects that …

Pain remains a very pervasive problem throughout medicine. Classical pain management is
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …

Structural modification of salvinorin A, the active component of Salvia divinorum, has
resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and …

Salvia divinorum is a perennial sage native to Oaxaca, Mexico, that has been used
traditionally in divination rituals and as a treatment for the “semimagical” disease panzón de …

The neoclerodane diterpene salvinorin A, found in the leaves of Salvia divinorum, is a potent
κ-opioid receptor agonist, making it an attractive scaffold for development into a treatment for …

Salvinorin A (SalA), a selective κ-opioid receptor (KOR) agonist, produces dysphoria and
pro-depressant like effects. These actions have been attributed to inhibition of striatal …

At present, the Mexican mint Salvia divinorum is an unregulated hallucinogen. This has
resulted in various on-line botanical companies advertising and selling S. divinorum as a …

The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid
receptor, an emerging target for next-generation analgesics. Here we review analogs of the …

Salvinorin A (1), from the sage Salvia divinorum, is a potent and selective κ opioid receptor
(KOR) agonist. We screened other salvinorins and derivatives for binding affinity and …

Salvia divinorum, a mint plant originally used by the Mazatecs of Oaxaca, Mexico in spiritual
rituals has gained popularity, in smoked form, as a legal hallucinogen in the United States …