Opioid receptors and legal highs: Salvia divinorum and Kratom
KM Babu, CR McCurdy, EW Boyer - Clinical toxicology, 2008 - Taylor & Francis
Salvia divinorum and Mitragyna speciosa (“Kratom”), two unscheduled dietary supplements
whose active agents are opioid receptor agonists, have discrete psychoactive effects that …
whose active agents are opioid receptor agonists, have discrete psychoactive effects that …
Natural products for the treatment of pain: chemistry and pharmacology of salvinorin A, mitragynine, and collybolide
S Chakraborty, S Majumdar - Biochemistry, 2020 - ACS Publications
Pain remains a very pervasive problem throughout medicine. Classical pain management is
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …
Neoclerodane diterpenes as a novel scaffold for μ opioid receptor ligands
WW Harding, K Tidgewell, N Byrd, H Cobb… - Journal of medicinal …, 2005 - ACS Publications
Structural modification of salvinorin A, the active component of Salvia divinorum, has
resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and …
resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and …
Neuropharmacology of the naturally occurring κ-opioid hallucinogen salvinorin A
Salvia divinorum is a perennial sage native to Oaxaca, Mexico, that has been used
traditionally in divination rituals and as a treatment for the “semimagical” disease panzón de …
traditionally in divination rituals and as a treatment for the “semimagical” disease panzón de …
Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues
The neoclerodane diterpene salvinorin A, found in the leaves of Salvia divinorum, is a potent
κ-opioid receptor agonist, making it an attractive scaffold for development into a treatment for …
κ-opioid receptor agonist, making it an attractive scaffold for development into a treatment for …
Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism
B Kivell, Z Uzelac, S Sundaramurthy… - …, 2014 - Elsevier
Salvinorin A (SalA), a selective κ-opioid receptor (KOR) agonist, produces dysphoria and
pro-depressant like effects. These actions have been attributed to inhibition of striatal …
pro-depressant like effects. These actions have been attributed to inhibition of striatal …
Psychopharmacology of the hallucinogenic sage Salvia divinorum
TE Prisinzano - Life sciences, 2005 - Elsevier
At present, the Mexican mint Salvia divinorum is an unregulated hallucinogen. This has
resulted in various on-line botanical companies advertising and selling S. divinorum as a …
resulted in various on-line botanical companies advertising and selling S. divinorum as a …
A review of salvinorin analogs and their kappa-opioid receptor activity
JJ Roach, RA Shenvi - Bioorganic & medicinal chemistry letters, 2018 - Elsevier
The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid
receptor, an emerging target for next-generation analgesics. Here we review analogs of the …
receptor, an emerging target for next-generation analgesics. Here we review analogs of the …
Studies toward the pharmacophore of salvinorin A, a potent κ opioid receptor agonist
Salvinorin A (1), from the sage Salvia divinorum, is a potent and selective κ opioid receptor
(KOR) agonist. We screened other salvinorins and derivatives for binding affinity and …
(KOR) agonist. We screened other salvinorins and derivatives for binding affinity and …
Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans
JM Hooker, Y Xu, W Schiffer, C Shea, P Carter… - Neuroimage, 2008 - Elsevier
Salvia divinorum, a mint plant originally used by the Mazatecs of Oaxaca, Mexico in spiritual
rituals has gained popularity, in smoked form, as a legal hallucinogen in the United States …
rituals has gained popularity, in smoked form, as a legal hallucinogen in the United States …