Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Both the consumption of a diet rich in fatty acids and exercise training result in similar
adaptations in several skeletal muscle proteins. These adaptations are involved in fatty acid …

Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …

Background Mitochondrial oxidative function plays a key role in the development of non-
alcoholic fatty liver disease (NAFLD) and insulin resistance (IR). Recent studies reported …

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing globally. NAFLD
includes non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). NASH is …

L-carnitine transports fatty acids into the mitochondria for oxidation and also buffers excess
acetyl-CoA away from the mitochondria. Thus, L-carnitine may play a key role in maintaining …

Medium-chain fatty acids (MCFAs) have in rodents been shown to have protective effects on
glucose homeostasis during high-fat overfeeding. In this study, we investigated whether …

Background Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly
associated with African ancestry are major contributors to the large racial disparity in rates of …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical setting. Its
pathogenesis was associated with metabolic disorder, especially defective fatty acids …

Background Redirecting glucose from skeletal muscle and adipose tissue, likely benefits the
tumor's energy demand to support tumor growth, as cancer patients with type 2 diabetes …