Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment.
However, tumor adjuvant therapy still faces challenges due to the intrinsic heterogeneity of …

Ovarian cancer (OC) represents the main cause of death from gynecological malignancies
in western countries. Altered cellular and mitochondrial metabolism are considered …

Mitochondrial dynamics are balanced fission and fusion events that regulate mitochondrial
morphology, and alteration in these events results in mitochondrial dysfunction and …

Ovarian cancer (OC) is the most lethal gynecologic malignancy, and melatonin has shown
various antitumor properties. Herein, we investigated the influence of melatonin therapy on …

Mitochondria are dynamic organelles that are important for cell growth and proliferation.
Dysregulated mitochondrial dynamics are highly associated with the initiation and …

Simple Summary Mitochondria, which play crucial roles in energy production and in
maintaining cellular homeostasis, are potential therapeutic targets in a variety of diseases …

Per-and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants
associated with adverse reproductive outcomes including reproductive cancers in women …

Aberrant mitochondrial fission/fusion dynamics are frequently associated with pathologies,
including cancer. We show that alternative splice variants of the fission protein Drp1 …

Chemotherapy failure in pancreatic cancer patients is widely attributed to cancer cell
reprogramming towards drug resistance by cancer associated fibroblasts (CAFs), which are …

Ovarian cancer is the most lethal gynecologic malignancy with a stubborn mortality rate of~
65%. The persistent failure of multiline chemotherapy, and significant tumor heterogeneity …