Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Genetic factors contribute to the phenotype of drug response. We systematically analyzed all
available pharmacogenetic data from Medline databases (1970–2003) on the impact that …

The application of pharmacogenetics holds great promise for individualized therapy.
However, it has little clinical reality at present, despite many claims. The main problem is that …

Objective: This review aimed to provide distinct dose recommendations for antidepressants
based on the genotypes of cytochrome P450 enzymes CYP2D6 and CYP2C19. This …

Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …

ABSTRACT Introduction: St. John's wort (SJW) is a common medicinal herb used for the
treatment of mild to moderate depression. Hyperforin, one of the chief components of SJW …

Patients with mental disorders have an increased risk to develop cardiovascular disease
(CVD), and CVD are frequently comorbid with especially adjustment, anxiety and depressive …

Objectives: More than 40 drugs are available to treat affective disorders. Individual selection
of the optimal drug and dose is required to attain the highest possible efficacy and …