The cellular environment where tumor cells reside is called the tumor microenvironment
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …

Thrombospondins TSP-1 and TSP-2 are potent endogenous inhibitors of angiogenesis.
They inhibit angiogenesis through direct effects on endothelial cell migration, proliferation …

Thrombospondins are evolutionarily conserved, calcium-binding glycoproteins that undergo
transient or longer-term interactions with other extracellular matrix components. They share …

The multifaceted action of thrombospondin-1 (TSP-1) depends on its ability to physically
interact with different ligands, including structural components of the extracellular matrix …

Investigations over the last decade have established the essential role of growth factors and
their receptors during angiogenesis and carcinogenesis. The vascular endothelial growth …

CD47 is a widely expressed integral membrane protein that serves as the counter-receptor
for the inhibitory phagocyte receptor signal-regulatory protein-α (SIRPα) and as a signaling …

Thrombospondin-1 (TSP1) can inhibit angiogenic responses directly by interacting with
VEGF and indirectly by engaging several endothelial cell TSP1 receptors. We now describe …

Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in
the developed world. Current therapy includes monthly intraocular injections of anti-VEGF …

Considerable progress has been made in our understanding of the process of angiogenesis
in the context of normal and tumor tissue over the last fifty years. Angiogenesis, like most …

Recent advances provide evidence that the cellular signalling pathway comprising the
ligand-receptor duo of thrombospondin-1 (TSP1) and CD47 is involved in mediating a range …