The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state
yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells …

Vascular engineering seeks to design and construct functional blood vessels comprising
endothelial cells (ECs) and perivascular cells (PCs), with the ultimate goal of clinical …

Aims Embryonic vascular smooth muscle cells (vSMCs) have a synthetic phenotype; in
adults, they commit to the mature contractile phenotype. Research shows that human …

Organ‐on‐a‐chip platforms seek to recapitulate the complex microenvironment of human
organs using miniaturized microfluidic devices. Besides modeling healthy organs, these …

Vascular smooth muscle cells (SMCs) arise from diverse developmental origins. Regional
distribution of vascular diseases may, in part, be attributed to this inherent heterogeneity in …

The formation of vasculature is essential for tissue maintenance and regeneration. During
development, the vasculature forms via the dual processes of vasculogenesis and …

Designing biomimetic scaffolds with in vivo–like microenvironments using biomaterials is an
essential component of successful tissue engineering approaches. The intestinal smooth …

Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in
children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in …

Vascular stem/progenitor cells (VSCs) are an important source of all types of vascular cells
needed to build, maintain, repair, and remodel blood vessels. VSCs, therefore, play critical …

Birth defects, which are in part caused by exposure to environmental chemicals and
pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The …