Induced pluripotent stem cells in cardiovascular drug discovery
The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state
yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells …
yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells …
Perivascular cells in blood vessel regeneration
Vascular engineering seeks to design and construct functional blood vessels comprising
endothelial cells (ECs) and perivascular cells (PCs), with the ultimate goal of clinical …
endothelial cells (ECs) and perivascular cells (PCs), with the ultimate goal of clinical …
Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells
M Wanjare, F Kuo, S Gerecht - Cardiovascular research, 2013 - academic.oup.com
Aims Embryonic vascular smooth muscle cells (vSMCs) have a synthetic phenotype; in
adults, they commit to the mature contractile phenotype. Research shows that human …
adults, they commit to the mature contractile phenotype. Research shows that human …
Biomechanical strain exacerbates inflammation on a progeria‐on‐a‐chip model
Organ‐on‐a‐chip platforms seek to recapitulate the complex microenvironment of human
organs using miniaturized microfluidic devices. Besides modeling healthy organs, these …
organs using miniaturized microfluidic devices. Besides modeling healthy organs, these …
Directed differentiation of embryonic origin–specific vascular smooth muscle subtypes from human pluripotent stem cells
Vascular smooth muscle cells (SMCs) arise from diverse developmental origins. Regional
distribution of vascular diseases may, in part, be attributed to this inherent heterogeneity in …
distribution of vascular diseases may, in part, be attributed to this inherent heterogeneity in …
Harnessing developmental processes for vascular engineering and regeneration
The formation of vasculature is essential for tissue maintenance and regeneration. During
development, the vasculature forms via the dual processes of vasculogenesis and …
development, the vasculature forms via the dual processes of vasculogenesis and …
Bi‐layered tubular microfiber scaffolds as functional templates for engineering human intestinal smooth muscle tissue
Designing biomimetic scaffolds with in vivo–like microenvironments using biomaterials is an
essential component of successful tissue engineering approaches. The intestinal smooth …
essential component of successful tissue engineering approaches. The intestinal smooth …
Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
PR Pitrez, L Estronca, LM Monteiro, G Colell… - Nature …, 2020 - nature.com
Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in
children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in …
children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in …
Vascular stem/progenitor cells: functions and signaling pathways
W Lu, X Li - Cellular and Molecular Life Sciences, 2018 - Springer
Vascular stem/progenitor cells (VSCs) are an important source of all types of vascular cells
needed to build, maintain, repair, and remodel blood vessels. VSCs, therefore, play critical …
needed to build, maintain, repair, and remodel blood vessels. VSCs, therefore, play critical …
High-throughput identification of small molecules that affect human embryonic vascular development
H Vazão, S Rosa, T Barata, R Costa… - Proceedings of the …, 2017 - National Acad Sciences
Birth defects, which are in part caused by exposure to environmental chemicals and
pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The …
pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The …