Vestibular epithelia of the inner ear detect head motions over a wide range of amplitudes
and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of …

Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …

In cases of acquired sensorineural hearing loss, death of cochlear neurons is thought to
arise largely as a result of sensory-cell loss. However, recent studies of acoustic …

Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory
neuron survival and establishment of neuronal projections to sensory epithelia in the …

In acquired sensorineural hearing loss, such as that produced by noise or aging, there can
be massive loss of the synaptic connections between cochlear sensory cells and primary …

Loss of synapses between spiral ganglion neurons and inner hair cells (IHC synaptopathy)
leads to an auditory neuropathy called hidden hearing loss (HHL) characterized by normal …

Sensory epithelia of the inner ear contain two major cell types: hair cells and supporting
cells. It has been clear for a long time that hair cells play critical roles in mechanoreception …

Overexposure to intense noise can destroy the synapses between auditory nerve fibers and
their hair cell targets without destroying the hair cells themselves. In adult mice, this …

Ribbon synapses of cochlear inner hair cells (IHCs) undergo molecular assembly and
extensive functional and structural maturation before hearing onset. Here, we characterized …

Spiral ganglion neurons (SGNs) are postsynaptic to hair cells and project to the brainstem.
The inner hair cell (IHC) to SGN synapse is susceptible to glutamate excitotoxicity and to …