β-Carboline as a privileged scaffold for multitarget strategies in Alzheimer's disease therapy

A Beato, A Gori, B Boucherle… - Journal of Medicinal …, 2021 - ACS Publications
The natural β-carboline alkaloids display similarities with neurotransmitters that can be
favorably exploited to design bioactive and bioavailable drugs for Alzheimer's disease (AD) …

Natural alkaloids as multi-target compounds towards factors implicated in Alzheimer's disease

R Vrabec, G Blunden, L Cahlíková - International Journal of Molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia in elderly people;
currently, there is no efficient treatment. Considering the increase in life expectancy …

Recent developments in new therapeutic agents against Alzheimer and Parkinson diseases: in-silico approaches

P Cruz-Vicente, LA Passarinha, S Silvestre, E Gallardo - Molecules, 2021 - mdpi.com
Neurodegenerative diseases (ND), including Alzheimer's (AD) and Parkinson's Disease
(PD), are becoming increasingly more common and are recognized as a social problem in …

[HTML][HTML] Evaluation of pyrimidine/pyrrolidine-sertraline based hybrids as multitarget anti-Alzheimer agents: In-vitro, in-vivo, and computational studies

MA Javed, MS Jan, AM Shbeer, M Al-Ghorbani… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is a complex, multifactorial and most prevalent progressive
neurodegenerative ailment. Its multifactorial and complex nature causes the lack of disease …

Rational drug design strategies for the development of promising multi-target directed indole hybrids as Anti-Alzheimer agents

N George, MJ Akhtar, KA Al Balushi, SA Khan - Bioorganic Chemistry, 2022 - Elsevier
Alzheimer's disease (AD) is a neurological disorder that leads to dementia ie, progressive
memory loss accompanied with worsening of thinking ability of an individual. The cause of …

Recent advance on pleiotropic cholinesterase inhibitors bearing amyloid modulation efficacy

H Zhang, Y Peng, L Zhuo, Y Wang, G Zeng… - European Journal of …, 2022 - Elsevier
Due to the hugely important roles of neurotransmitter acetylcholine (ACh) and amyloid-β
(Aβ) in the pathogenesis of Alzheimer's disease (AD), the development of multi-target …

Effects and mechanisms of natural products on Alzheimer's disease

Z Yang, DD Zhou, SY Huang, AP Fang… - Critical Reviews in …, 2023 - Taylor & Francis
Alzheimer's disease (AD) is the most common form of dementia in elderly people with a high
incidence rate and complicated pathogenesis, and causes progressive cognitive deficit and …

Insights into the explicit protective activity of herbals in management of neurodegenerative and cerebrovascular disorders

T Behl, R Makkar, A Sehgal, N Sharma, S Singh… - Molecules, 2022 - mdpi.com
The longstanding progressive neurodegenerative conditions of the central nervous system
arise mainly due to deterioration, degradation and eventual neuronal cell loss. As an …

[Retracted] Identification of Potential Poly (ADP‐Ribose) Polymerase‐1 Inhibitors Derived from Rauwolfia serpentina: Possible Implication in Cancer Therapy

AM Abuzenadah, F Al-Sayes… - Evidence‐Based …, 2022 - Wiley Online Library
Poly (ADP‐ribose) polymerase‐1 (PARP‐1) has been recognized as a prospective target for
the development of novel cancer therapeutics. Several PARP‐1 inhibitors are currently …

4F-indole enhances the susceptibility of Pseudomonas aeruginosa to aminoglycoside antibiotics

Q Dou, Y Zhu, C Li, Z Bian, H Song, R Zhang… - Microbiology …, 2023 - Am Soc Microbiol
Infections caused by multidrug-resistant bacteria are becoming increasingly serious. The
aminoglycoside antibiotics have been widely used to treat severe Gram-negative bacterial …