Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

Interleukin-12 is considered a potent agent to enhance antitumor immune responses. It
belongs to a family of heterodimeric cytokines with key roles in the up-regulation and down …

Combination therapy and nanotechnology offer a promising therapeutic method in cancer
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …

Gene therapy is now being applied to the treatment of a wide variety of acquired and
inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency …

Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …

Genetically engineered, neuroattenuated herpes simplex viruses (HSVs) expressing various
cytokines can improve survival when used in the treatment of experimental brain tumors …

T-helper 1 (Th1) cells are believed to be the major producer of the type 1 cytokine interferon-
γ (IFN-γ) in cell-mediated immunity against intracellular infection. We have investigated the …

Brucella abortus is a facultative intracellular bacterium that infects humans and domestic
animals. The enhanced susceptibility to virulent B. abortus observed in MyD88 knockout …

Tumor necrosis factor (TNF) is a proinflammatory cytokine which has recently been shown to
have beneficial effects in the setting of acquired host immunity. However, the role of TNF in …

Abstract Interleukin-12 (IL-12) is unique amongst cytokines in being a disulfide-linked
heterodimer of two separately encoded subunits (p35 and p40). We expressed single chain …