Application of the Nicoya OpenSPR to Studies of Biomolecular Binding: A Review of the Literature from 2016 to 2022
EK Hanson, RJ Whelan - Sensors, 2023 - mdpi.com
The Nicoya OpenSPR is a benchtop surface plasmon resonance (SPR) instrument. As with
other optical biosensor instruments, it is suitable for the label-free interaction analysis of a …
other optical biosensor instruments, it is suitable for the label-free interaction analysis of a …
A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein
The receptor-binding domain (RBD) in S1 subunit and heptad repeat 1 (HR1) domain in S2
subunit of SARS-CoV-2 spike (S) protein are the targets of neutralizing antibodies (nAbs) …
subunit of SARS-CoV-2 spike (S) protein are the targets of neutralizing antibodies (nAbs) …
An HR2-mimicking sulfonyl-γ-AApeptide is a potent pan-coronavirus fusion inhibitor with strong blood–brain barrier permeability, long half-life, and promising oral …
Neutralizing antibodies and fusion inhibitory peptides have the potential required to combat
the global pandemic caused by SARS-CoV-2 and its variants. However, the lack of oral …
the global pandemic caused by SARS-CoV-2 and its variants. However, the lack of oral …
The global patent landscape of HER2-targeted biologics
Q Li, J Xu, Q Sun, Z Zhang, Y Hu, H Yao - Nature Biotechnology, 2023 - nature.com
The global patent landscape of HER2-targeted biologics | Nature Biotechnology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …
content Thank you for visiting nature.com. You are using a browser version with limited support …
[HTML][HTML] α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo
Peptides are increasingly important resources for biological and therapeutic development,
however, their intrinsic susceptibility to proteolytic degradation represents a big hurdle. As a …
however, their intrinsic susceptibility to proteolytic degradation represents a big hurdle. As a …
A Multivalent DNA Nanoparticle/Peptide Hybrid Molecular Modality for the Modulation of Protein–Protein Interactions in the Tumor Microenvironment
JA Roman, MY Girgis, RS Prisby… - Advanced …, 2024 - Wiley Online Library
Despite success in the treatment of some blood cancers and melanoma, positive response
to immunotherapies remains disappointingly low in the treatment of solid tumors. The …
to immunotherapies remains disappointingly low in the treatment of solid tumors. The …
[HTML][HTML] Editorial of Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”
Since insulin, a natural peptide composed of 51 amino acids, was first isolated and
commercialized in the 1920s, peptide drugs have greatly reshaped our modern drug …
commercialized in the 1920s, peptide drugs have greatly reshaped our modern drug …
The discovery of cyclic γ-AApeptides as the promising ligands targeting EP2
EP2 is a G protein-coupled receptor for prostaglandin E2 (PGE2) derived from cell
membrane-released arachidonic acid upon various harmful and injurious stimuli. It is …
membrane-released arachidonic acid upon various harmful and injurious stimuli. It is …
Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization
C Dai, C Lian, H Fang, Q Luo, J Huang, M Yang… - Organic …, 2022 - ACS Publications
The diversity of cyclic peptides was expanded by elaborating Mitsunobu macrocyclization,
tethering various hydroxy acid building blocks with different Nε-amine substituents. This new …
tethering various hydroxy acid building blocks with different Nε-amine substituents. This new …