Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Interest in cancer metabolism has increased in recent years. The pentose phosphate
pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its …

There has been significant progress in utilizing our immune system against cancer, mainly
by checkpoint blockade and T cell-mediated therapies. The field of cancer immunotherapy is …

Abstract Purpose: Treatment of BRAFV600E-mutant melanomas with MAPK inhibitors
(MAPKi) results in significant tumor regression, but acquired resistance is pervasive. To …

Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …

Drug resistance invariably limits the response of oncogene-addicted cancer cells to targeted
therapy. The upregulation of signal transducer and activator of transcription 3 (STAT3) has …

Conversion of normal cells to cancer is accompanied with changes in their metabolism.
During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to …

Improvement of hyperglycemia through dietotherapy/herbal remedy is an effective approach
to treating diabetes. In this study, mulberry leaf, famous for silkworm's special food and …

Cancer metabolism is characterized by an accelerated glycolytic rate facing reduced activity
of oxidative phosphorylation. This “Warburg effect” represents a standard to diagnose and …

Identifying oncological applications for drugs that are already approved for other medical
indications is considered a possible solution for the increasing costs of cancer treatment …