Infectious disease prevention and control has been among the top public health objectives
during the last century. However, controlling disease due to pathogens that move between …

This review provides a brief history of the impacts that a human-specific Orthopoxvirus
(OPXV), Variola virus, had on mankind, recalls how critical vaccination was for the …

Highlights•Viruses in the genus Orthopoxvirus have differing host-range phenotypes.•
Hypothetical ancestral state is a broad host range virus with large genome.•Selection for …

Vaccinia virus (VACV), the prototype species of the Orthopoxvirus (OPV) genus, causes an
occupational zoonotic disease in Brazil that is primarily associated with the handling of …

The orthopoxviruses (OPV) comprise several emerging viruses with great importance to
human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of …

Background Animal-borne orthopoxviruses, like monkeypox, vaccinia and the closely
related cowpox virus, are all capable of causing zoonotic infections in humans, representing …

Vaccinia virus (VACV) is a promising oncolytic agent because it exhibits many characteristic
features of an oncolytic virus. However, its effectiveness is limited by the strong antiviral …

Smallpox was declared eradicated in 1980 after an intensive vaccination program using
different strains of vaccinia virus (VACV; Poxviridae). VACV strain IOC (VACV-IOC) was the …

The threat of smallpox as a bioweapon and the emerging threat of human monkeypox,
among other poxviral diseases, highlight the need for effective poxvirus countermeasures …

Vaccinia virus (VACV) is a zoonotic agent that causes a disease called bovine vaccinia,
which is detected mainly in milking cattle and humans in close contact with these animals …