How do lncRNAs regulate transcription?
It has recently become apparent that RNA, itself the product of transcription, is a major
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
Nuclear long noncoding RNAs: key regulators of gene expression
A significant portion of the human genome encodes genes that transcribe long nonprotein-
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma
Background Histone lactylation, a metabolic stress-related histone modification, plays an
important role in the regulation of gene expression during M1 macrophage polarization …
important role in the regulation of gene expression during M1 macrophage polarization …
RNA-based diagnostic markers discovery and therapeutic targets development in cancer
H Wang, Q Meng, J Qian, M Li, C Gu, Y Yang - Pharmacology & …, 2022 - Elsevier
The present review aimed to outline different types of RNAs in cancer diagnostics and
treatment, and to provide novel insights into their clinical applications. RNAs, including …
treatment, and to provide novel insights into their clinical applications. RNAs, including …
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
Y Song, J Sun, J Zhao, Y Yang, J Shi, Z Wu… - Nature …, 2017 - nature.com
Thousands of genes have been well demonstrated to play important roles in cancer
progression. As genes do not function in isolation, they can be grouped into “networks” …
progression. As genes do not function in isolation, they can be grouped into “networks” …
[HTML][HTML] lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment
H Jin, W Du, W Huang, J Yan, Q Tang, Y Chen… - … Therapy-Nucleic Acids, 2021 - cell.com
Breast cancer is a malignant tumor that has a high mortality rate and mostly occurs in
women. Although significant progress has been made in the implementation of personalized …
women. Although significant progress has been made in the implementation of personalized …
From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis
S Dhamija, S Diederichs - International journal of cancer, 2016 - Wiley Online Library
Metastasis is a multistep process that involves the dissemination of cells from the primary
tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a …
tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a …
Endogenous retroviral promoter exaptation in human cancer
Cancer arises from a series of genetic and epigenetic changes, which result in abnormal
expression or mutational activation of oncogenes, as well as suppression/inactivation of …
expression or mutational activation of oncogenes, as well as suppression/inactivation of …
Mechanisms of long non-coding RNAs in cancers and their dynamic regulations
XZ Zhang, H Liu, SR Chen - Cancers, 2020 - mdpi.com
Long non-coding RNA (lncRNA), which is a kind of noncoding RNA, is generally
characterized as being more than 200 nucleotide transcripts in length. LncRNAs exhibit …
characterized as being more than 200 nucleotide transcripts in length. LncRNAs exhibit …